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Some strands of Escherichia coli can have the polyketide synthetase (pks) island that encodes colibactin, a genotoxic compound that will alkylate DNA on adenine residues and induce point mutations with a specific signature12,thirteen (COSMIC SBS88). Moreover, exposure to pks+ E. coli generates a attribute limited indel signature (COSMIC ID18) which manifests as quick T deletions at T homopolymers10. Pks+ E.coli is located in colon cancer14,fifteen and the corresponding signature continues to be detected in cell’s genomes in both of those normal9 and cancer12,thirteen. Even so, to our knowledge it hasn't been nonetheless identified in regular colon of cancer sufferers (suggesting prolonged exposure), as detailed analyses of matched regular and cancer tissues from your similar affected individual are missing.
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Intratumoral microbiota in colorectal cancer: give attention to specific distribution and opportunity mechanisms Jing more info Long
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